How MK-677 Works
MK-677 works as growth hormone pulse intensifier, which can be
increase through four possible mechanisms:
|1||Increasing the release of GHRH, or “Growth Hormone Releasing
|2||Amplifying GHRH signaling in the somatotrophs of the anterior
|3||Reducing somatostatin release, which “turns of” the release of
|4||Inhibiting the signaling of the somatostatin receptor|
The incredible part being that MK-677 was found to successfully
maneuver through all four of these mechanisms. Post-ingestion,
growth hormone levels were shown to increase, relative to dosage,
starting at 5 mg per day.
The most common doses of MK-677 range between 5-25mgs per day. In
some cases, we’ve seen doses upwards of 50mgs per day, but these
are few and far between, and didn’t result in exponential benefits
above the recommended top-end dosage of 20-25mgs per day.
Here is an example of a Nutrobal + Cardarine + Andarine Cycle
NOTE: Only ramp up andarine if you have the dosing schedule and
side effects schedule properly planned. Otherwise, stick to a lower
MK-677 Side Effects
Some of the usual side effects that go with elevated GH levels such
as numb hands, some lethargy, as well as slight increased appetite
have been reported with the use of Mk-677.
Interestingly, during prolonged administration both IGF-1 and GH
were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small
increase in prolactin when beginning administration, so individuals
who are very prone to prolactin side effect may want to incorporate
a short schedule of HCGenerate ES to prevent problems. I want to
stress, this is only an issue for guys who are extremely prone to
prolactin sides, which is usually 1% of users. How do you know if
you're prone to prolactin sides? If you get gynecomastia from
taking trenbolone, you're prone to prolactin sides.