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77191-36-7 Nefiracetam DMMPA

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77191-36-7 Nefiracetam DMMPA

Brand Name : Jusheng Brand
Model Number : 77191-36-7
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 77191-36-7
Apparence : Almost White Crystalline Powder
Purity : 99.5%
Usage : Cognitive Enhancer Drugs
Stock : Available
Deliver time : 5 TO 7 Working Days
Other Name : Nefiracetam, DMMPA
Grade : Pharma Grade
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Nefiracetam DMMPA Raw Material Drug For Cognitive Enhancer 77191-36-7 Powder

Quick detail


Product name: Nefiracetam
No:77191-36-7

Alternative Name: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide

Biological Activity
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems.

Technical Data

M.Wt: 246.3

Formula: C14H18N2O2

Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity: >99 %

Storage: Store at RTCAS


Nefiracetam Introduction


Nefiracetam is a relatively less-known nootropic of the racetam family, which is derived from piracetam. Its molecular structure (and thus properties) look similar to aniracetam, but nefiracetam is considered more potent than the two stated racetams. Nefiracetam was initially introduced as a useful supplement for dementia patients, but soon after its introduction, it was also recognized as a nootropic drug providing excellent benefits to cognitive functions.


Nefiracetam Works:


There are two reported pathways for mechanism of action by administration of nefiracetam. The first one is the prolonged opening of calcium channels which elevates the brain stimulation. This improves the memory formation as well as extends the neuro-communication among different sites within the brain. The second pathway is to increase production of certain neuro-transmitters (like GABA, Glutamate etc.) within brain which results in relief from depression, anxiety and mental stress as well as facilitates the neuro-transmission.


Nefiracetam is capable of crossing the blood-brain barrier, a built-in guard mechanism to inhibit entrance of toxic or higher doses of chemicals to the brain via the blood stream. It has been shown that nefiracetam is effective after a regular use for few days, whereas a single fraction results in no effect literally.


How to Take Nefiracetam?

The best way to use Nefiracetam is by splitting up your total daily use into several different equally divided administrations.Most experts suggest taking your 150 to 450 mg dose in three shots, normally with a meal since it is fat soluble.The reason for the split doses is due to the fact that this supplement is very fast acting, reaching and affecting the brain within 30 to 60 minutes.Additionally, due to the half-life, these frequent doses enable the active ingredients to remain in a more or less consistent supply/level throughout the day.



Nefiracetam Effect:


The supplement is shown to be used for a number of benefits including treatments for dementia, seizures, depression etc. as well as neuro-protection and cognition enhancement.

Although not many studies can confirm, Nefiracetam is able to increase memory formation when taken daily over a prolonged period of time. It is known to open calcium channels which prolongs its presence in the activated neuron before increasing signaling of acetylcholine and glutamate at the synapse. This ability gives Nefiracetam nootropic value.

Nefiracetam has been studied on animals as well to understand its interactions with hormones. It was found about one week after Nefiracetam was given to beagle dogs, that it was able to reduce serum testosterone while increasing circulating estrogen serum concentrations,


STUDIES ON NEFIRACETAM


Limited studies on humans exist, but animal studies are carried out for a number of diseases. In some of studies, nefiracetam is shown to possess anti-amnestic properties, preventing a partial or total memory loss. Few other studies have termed it as anti-convulsion drug based on experiments revealing its benefits in the patients with epilepsy, dementia, Alzheimer disorder etc. The most famous term assigned to nefiracetam is anti-dementia. Some studies also exist on the anti-depressant/anti-apathy effects of nefiracetam. Overall, it has been shown to possess neuro-protective, anti-depressant and cognitive effects for animals as well as humans.


RECOMMENDED DOSAGE / USAGE INSTRUCTIONS


Recommendations vary, however most sources suggest between 150mg and 450mg per day. Preferably spread across morning, midday and evening. To find your personal optimum it is advised to start with low doses and gradually increase dose until a personal optimum is reached.

Nefiracetam fat-soluble and it is therefore recommended to be taken along with fatty acids (foods containing fat).


SIDE-EFFECTS OF NEFIRACETAM


Till now, no toxicity is reported for humans, and nefiracetam is considered safe up to an optimum dosage, varying by each individual. The common side effects are similar to those exhibited by all racetams, such as headache, nausea, dizziness, stomach distress etc. Headaches can be protected against having a choline-rich diets. All side-effects are more prone to occur when ingesting higher doses.

CAUTION

Nefiracetam does not go well with Glycine and other NDMA glycine binding ligands.


Other Pharmaceutical Raw Material


Brivaracetam

CAS 357336-20-0

Etiracetam

CAS 3996-58-6

Oxiracetam

CAS 62613-82-5

Aniracetam

CAS 72432-10-1

Levetiracetam

CAS 102767-28-2

Nefiracetam

CAS 77191-36-7

Pramiracetam

CAS 68497-62-1

Piracetam

CAS 7491-74-9

COLURACETAM

CAS135463-81-9


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