Nefiracetam DMMPA Raw Material Drug For Cognitive Enhancer
Product name: Nefiracetam
Alternative Name: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Cognitive enhancer that displays various pharmacological effects.
Activates L/N-type calcium channels, cholinergic, monoaminergic and
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity: >99 %
Storage: Store at RTCAS
Nefiracetam is a relatively less-known nootropic of the racetam
family, which is derived from piracetam. Its molecular structure
(and thus properties) look similar to aniracetam, but nefiracetam
is considered more potent than the two stated racetams. Nefiracetam
was initially introduced as a useful supplement for dementia
patients, but soon after its introduction, it was also recognized
as a nootropic drug providing excellent benefits to cognitive
There are two reported pathways for mechanism of action by
administration of nefiracetam. The first one is the prolonged
opening of calcium channels which elevates the brain stimulation.
This improves the memory formation as well as extends the
neuro-communication among different sites within the brain. The
second pathway is to increase production of certain
neuro-transmitters (like GABA, Glutamate etc.) within brain which
results in relief from depression, anxiety and mental stress as
well as facilitates the neuro-transmission.
Nefiracetam is capable of crossing the blood-brain barrier, a
built-in guard mechanism to inhibit entrance of toxic or higher
doses of chemicals to the brain via the blood stream. It has been
shown that nefiracetam is effective after a regular use for few
days, whereas a single fraction results in no effect literally.
How to Take Nefiracetam?
The best way to use Nefiracetam is by splitting up your total daily
use into several different equally divided administrations.Most
experts suggest taking your 150 to 450 mg dose in three shots,
normally with a meal since it is fat soluble.The reason for the
split doses is due to the fact that this supplement is very fast
acting, reaching and affecting the brain within 30 to 60
minutes.Additionally, due to the half-life, these frequent doses
enable the active ingredients to remain in a more or less
consistent supply/level throughout the day.
The supplement is shown to be used for a number of benefits
including treatments for dementia, seizures, depression etc. as
well as neuro-protection and cognition enhancement.
Although not many studies can confirm, Nefiracetam is able to
increase memory formation when taken daily over a prolonged period
of time. It is known to open calcium channels which prolongs its
presence in the activated neuron before increasing signaling of
acetylcholine and glutamate at the synapse. This ability gives
Nefiracetam nootropic value.
Nefiracetam has been studied on animals as well to understand its
interactions with hormones. It was found about one week after
Nefiracetam was given to beagle dogs, that it was able to reduce
serum testosterone while increasing circulating estrogen serum
STUDIES ON NEFIRACETAM
Limited studies on humans exist, but animal studies are carried out
for a number of diseases. In some of studies, nefiracetam is shown
to possess anti-amnestic properties, preventing a partial or total
memory loss. Few other studies have termed it as anti-convulsion
drug based on experiments revealing its benefits in the patients
with epilepsy, dementia, Alzheimer disorder etc. The most famous
term assigned to nefiracetam is anti-dementia. Some studies also
exist on the anti-depressant/anti-apathy effects of nefiracetam.
Overall, it has been shown to possess neuro-protective,
anti-depressant and cognitive effects for animals as well as
RECOMMENDED DOSAGE / USAGE INSTRUCTIONS
Recommendations vary, however most sources suggest between 150mg
and 450mg per day. Preferably spread across morning, midday and
evening. To find your personal optimum it is advised to start with
low doses and gradually increase dose until a personal optimum is
Nefiracetam fat-soluble and it is therefore recommended to be taken
along with fatty acids (foods containing fat).
SIDE-EFFECTS OF NEFIRACETAM
Till now, no toxicity is reported for humans, and nefiracetam is
considered safe up to an optimum dosage, varying by each
individual. The common side effects are similar to those exhibited
by all racetams, such as headache, nausea, dizziness, stomach
distress etc. Headaches can be protected against having a
choline-rich diets. All side-effects are more prone to occur when
ingesting higher doses.
Nefiracetam does not go well with Glycine and other NDMA glycine
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