Anti-depressant MKC-231Active Pharmaceutical Ingredients
Coluracetam Smart Drugs
Brain health drug;Nootropic
|Solubility:||soluble in DMSO and Ethanol|
Coluracetam belongs to the wider group of racetam drugs. It is
often touted for its memory boosting properties as well as its
positive effects on manic depression and anxiety. Although
coluracetam is mainly associated with these benefits, it has also
been reported to boost optic properties although ongoing studies
are needed to identify the exact mechanisms behind this benefit.
Since the study subjects were rats, there aren’t any recommended
Anecdotally, nootropic users report dosing in the range of 3-35 mg
up to 3x per day. It is generally advised to begin dosing at the
lower side of the ranges to determine your reaction to the
substance and work up as desired.
There isn’t very much information to indicate toxicity of
coluracetam, although doses given at the above increments showed no
adverse side effects. If you haven’t used a nootropic before, you
may develop a headache after use, which is a common side effect in
first-time users. By stacking coluracetam with a bioavailable
choline source, you’ll likely reduce this risk.
Like most Racetams, coluracetam stacks well with a choline source,
such as Alpha GPC, for added memory and cognitive benefits. The
recommended doses for supplemental choline is 300 mg to 600 mg
daily if you’re stacking with Alpha GPC and 250 mg to 750 mg daily
if you’re using CDP choline.
BENEFITS AND EFFECTS
After acquiring the license from Mitsubishi Tanabe Pharma
Corporation, BrainCells Inc. immediately began testing the effects
of coluracetam. As there weren’t enough participants to take part
in clinical trials for coluracetam, most of these tests were
conducted on rats instead. From these tests, coluracetam was shown
to markedly improve memory, learning, and anxiety.
Memory and Learning
|Coluracetam is shown to improve cognitive function and memory in
rats, and in theory, the same results are expected in human beings.
A study conducted by BrainCells Inc showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for
eight days along with coluracetam in 3 mg doses. They were then put
through the standardized Morris Water Maze to mark their ability to
get through it, and even up to 72 hours after the last 8 mg dose,
they were still able to. Another key finding of this study was that
the results were still apparent three days after the last dose,
even though the serum concentration of coluracetam was negligible.|
|Depression and Anxiety|BrainCells Inc. found that a dosage of 240 mg (split into three
daily doses of 80 mg) was useful in treating major depression with
co-morbid GAD (generalized anxiety disorder). However, the
differences were most pronounced in those who didn’t find relief in
using standard antidepressants. After one dose, there were no
noticeable differences, but after two doses of 80 mg, 36% had improved scores during a depression assessment test.
|Coluracetam has been associated with optic benefits such as
enhanced color vision, recognition, and vividness. Although there
isn’t any conclusive evidence to support the mechanisms behind this
benefit, experts believe that coluracetam works in the part of the
brain that runs visual processes.|
Coluracetam’s Mechanism of Action
Coluracetam appears to have two well-defined mechanisms of action;
the first being high-affinity choline uptake, and the other being
AMPA potentiation . As is the case with a few of the Racetams,
Coluracetam has been show to facilitate AMPA potentiation which is
known to increase alertness, memory, and learning capabilities.
What is more intriguing about Coluracetam are its high-affinity
choline uptake properties; choline uptake plays a crucial role in
the Acetylcholine synthesis process in the brain by acting as a
rate-limiter. This rate-limiting step allows the brain to convert
choline into Acetylcholine in the neuron, and by increasing the
high-affinity choline uptake the brain is more readily able to
convert choline to Acetylcholine; by increasing the ability to
convert choline to Acetylcholine, should in theory improve
attention, memory, and wakefulness in humans.
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