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Anti Depressant Coluracetam Powder

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Anti Depressant Coluracetam Powder

Brand Name : Jusheng Brand
Model Number : 135463-81-9
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 135463-81-9
Molecular Formula : C19H23N3O3
Apparence : Almost White Crystalline Powder
Purity : More Than 98%
MOQ : 10grams
Packing : As Your Requirement
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Anti-depressant MKC-231Active Pharmaceutical Ingredients Coluracetam Smart Drugs

Quick detail


Product nameColuracetam
Synonyms:BCI-540; MKC-231
CAS:135463-81-9
MF:C19H23N3O3
MW:341.4
Product Categories:

Brain health drug;Nootropic


Density:1.3
Boiling point:634.1ºC
Flash point:337.3ºC
Solubility:soluble in DMSO and Ethanol
Appearance:white powder
Purity:99%

Coluracetam​ Introduction


Coluracetam belongs to the wider group of racetam drugs. It is often touted for its memory boosting properties as well as its positive effects on manic depression and anxiety. Although coluracetam is mainly associated with these benefits, it has also been reported to boost optic properties although ongoing studies are needed to identify the exact mechanisms behind this benefit.


Coluracetam Dosing


Since the study subjects were rats, there aren’t any recommended human dosages.

Anecdotally, nootropic users report dosing in the range of 3-35 mg up to 3x per day. It is generally advised to begin dosing at the lower side of the ranges to determine your reaction to the substance and work up as desired.

There isn’t very much information to indicate toxicity of coluracetam, although doses given at the above increments showed no adverse side effects. If you haven’t used a nootropic before, you may develop a headache after use, which is a common side effect in first-time users. By stacking coluracetam with a bioavailable choline source, you’ll likely reduce this risk.


STACKING


Like most Racetams, coluracetam stacks well with a choline source, such as Alpha GPC, for added memory and cognitive benefits. The recommended doses for supplemental choline is 300 mg to 600 mg daily if you’re stacking with Alpha GPC and 250 mg to 750 mg daily if you’re using CDP choline.


BENEFITS AND EFFECTS


After acquiring the license from Mitsubishi Tanabe Pharma Corporation, BrainCells Inc. immediately began testing the effects of coluracetam. As there weren’t enough participants to take part in clinical trials for coluracetam, most of these tests were conducted on rats instead. From these tests, coluracetam was shown to markedly improve memory, learning, and anxiety.


Memory and Learning

Coluracetam is shown to improve cognitive function and memory in rats, and in theory, the same results are expected in human beings. A study conducted by BrainCells Inc showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for eight days along with coluracetam in 3 mg doses. They were then put through the standardized Morris Water Maze to mark their ability to get through it, and even up to 72 hours after the last 8 mg dose, they were still able to. Another key finding of this study was that the results were still apparent three days after the last dose, even though the serum concentration of coluracetam was negligible.
​Depression and Anxiety
BrainCells Inc. found that a dosage of 240 mg (split into three daily doses of 80 mg) was useful in treating major depression with co-morbid GAD (generalized anxiety disorder). However, the differences were most pronounced in those who didn’t find relief in using standard antidepressants. After one dose, there were no noticeable differences, but after two doses of 80 mg, 36% had improved scores during a depression assessment test.

Eyesight

Coluracetam has been associated with optic benefits such as enhanced color vision, recognition, and vividness. Although there isn’t any conclusive evidence to support the mechanisms behind this benefit, experts believe that coluracetam works in the part of the brain that runs visual processes.

Coluracetam’s Mechanism of Action


Coluracetam appears to have two well-defined mechanisms of action; the first being high-affinity choline uptake, and the other being AMPA potentiation [3]. As is the case with a few of the Racetams, Coluracetam has been show to facilitate AMPA potentiation which is known to increase alertness, memory, and learning capabilities. What is more intriguing about Coluracetam are its high-affinity choline uptake properties; choline uptake plays a crucial role in the Acetylcholine synthesis process in the brain by acting as a rate-limiter. This rate-limiting step allows the brain to convert choline into Acetylcholine in the neuron, and by increasing the high-affinity choline uptake the brain is more readily able to convert choline to Acetylcholine; by increasing the ability to convert choline to Acetylcholine, should in theory improve attention, memory, and wakefulness in humans.


Warnings


  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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