Raw Materials Tibolone / Livial Tibofem Anti-aging Drugs CAS
630-53-5 White Powder
|Appearance||Yellow or light yellow crystalline powder|
shading, confined preservation.
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Tibolone is a synthetic steroid hormone derived from the Mexican
The metabolites of tibolone have estrogenic, androgenic and
Tibolone has oestrogen-like effects in the brain (preventing
flushes), bone (preventing bone loss) and vaginal tissue
(preventing dryness and soreness)
Tibolone also has progesterone-like effects at the uterus to
prevent endometrial thickening and subsequent bleeding. A woman who
has not had a hysterectomy does not need to take a progestogen if
she is taking tibolone.
Tibolone has testosterone-like activity that appears to play a role
in enhancing women's mood and libido, although response is
Tibolone (INN, USAN, BAN) (brand name Livial, Tibofem), also known
as 7α-methylnoretynodrel,is a synthetic steroid drug with
estrogenic, progestogenic, and weak androgenic actions which was
introduced in 1988 and is used widely in Europe, Asia, Australasia,
and, with the exception of the United States (where it is not
available), the rest of the world. It is used mainly for treatment
of endometriosis, as well as hormone replacement therapy in
Tibolone has similar or greater efficacy compared to older hormone
replacement drugs, but shares a similar side effect profile. It has
also been investigated as a possible treatment for female sexual
How to take Tibolone
|Step One||Before you start taking the tablets, read the manufacturer's
printed information leaflet from inside your pack. The
manufacturer's leaflet will give you more information about
tibolone and a full list of the side-effects which you may
experience from taking it.|
|Step Two||Take one 2.5 mg tablet every day. You may take tibolone at whatever
time of day you find easiest to remember, but try to take your
doses at the same time of day, each day. You can take the tablets
before or after meals. You may find it helps to swallow the tablet
with a drink of water.|
|Step Three||If you forget to take a dose, take it as soon as you remember
unless you are more than 12 hours late. If you are more than 12
hours late, leave out the forgotten dose and take your next tablet
at the usual time. Do not take two tablets together to make up for
a missed dose.|
Before Taking Tibolone
Some medicines are not suitable for people with certain conditions,
and sometimes a medicine may only be used if extra care is taken.
For these reasons, before you start taking tibolone it is important
that your doctor or pharmacist knows:
- If you (or a close family member) have had breast cancer.
- If you have had a cancer that you have been told is
- If you have any unexplained vaginal bleeding.
- If you have liver disease, or if you have any problems with the way
your kidneys work.
- If you know you have high levels of fat (triglycerides or
cholesterol) in your blood.
- If you have ever had a blood clot in your leg or lungs, or if you
have had thrombophlebitis (inflammation of a vein).
- If you have angina, or if you have had a heart attack or stroke.
- If there is a possibility you might be pregnant.
- If you have diabetes mellitus.
- If you have migraines, or migraine-like headaches.
- If you have epilepsy.
- If you have gallstones.
- If you have a rare inherited blood condition, called porphyria.
- If you are taking any other medicines. This includes any medicines
you are taking which are available to buy without a prescription,
such as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
In this randomized study, we assigned 4538 women, who were between
the ages of 60 and 85 years and had a bone mineral density T score
of −2.5 or less at the hip or spine or a T score of −2.0 or less
and radiologic evidence of a vertebral fracture, to receive
once-daily tibolone (at a dose of 1.25 mg) or placebo. Annual spine
radiographs were used to assess for vertebral fracture. Rates of
cardiovascular events and breast cancer were adjudicated by expert