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CAS 656247-17-5 Nintedanib Powder

CAS 656247-17-5 Nintedanib Powder

Brand Name : Jusheng Brand
Model Number : 656247-17-5
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 656247-17-5
Apparence : White Powder
Purity : 99%
Other Name : Intedanib; Imidafenacin; Uritos; Staybla;
Usage : Treatment of Idiopathic Pulmonary Fibrosis (IPF)
Stock : Available
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Nintedanib CAS 656247-17-5 Treatment of Idiopathic Pulmonary Fibrosis (IPF) Powder

Quick detail

CAS No.:

Synonyms: methyl(3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;(Z)-N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide; Ofev; Vargatef; Intedanib; Imidafenacin; Uritos; Staybla;

Exact Mass:539.25300
Molecular Weight:539.62500

Nintedanib​ Description

Nintedanib, marketed under the brand names Ofev and Vargatef, is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.
Common side effects include abdominal pain, vomiting, and diarrhea. It is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).

How nintedanib Works

How nintedanib Works1. Nintedanib inhibits tyrosine kinase, an enzyme essential for signal transduction pathways that trigger growth factors like vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet derived growth factor receptor (PDGFR), which are secreted in excess amounts in patients with IPF.
2. These growth factors promote collagen production and deposition and help in the differentiation, maturation, and proliferation of the fibroblasts, which eventually lead to the formation of scar tissues in the lungs.
3. Nintedanib binds to the phosphorylating site of tyrosine kinase, which blocks the cell signaling mechanism, slowing the progression of the disease.

Nintedanib Sise Effect

side effects

The following side effects are associated with nintedanib:
Common side effects of nintedanib:

  • Abnormal Liver Function Tests Severe
  • High Blood Pressure Severe
  • DiarrheaLess Severe
  • Feel Like Throwing Up Less Severe
  • Head Pain Less Severe
  • Intense Abdominal Pain Less Severe
  • Loss of Appetite Less Severe
  • Throwing Up Less Severe
  • Weight Loss Less Severe

Infrequent side effects of nintedanib:

  • Acute Blood Clot in an Artery Severe
  • Heart Attack Severe
  • Hemorrhage Severe
  • lung cancer Severe
  • Bronchitis Less Severe
  • hypothyroidism Less Severe

Rare side effects of nintedanib:

  • A Rupture in the Wall of the Stomach or Intestine Severe
  • High Amount of Bilirubin in the Blood Severe
  • Pneumonia Severe

Do NOT use nintedanib if

  1. you are allergic to any ingredient in nintedanib
  2. you have moderate to severe liver problems
  3. you take carbamazepine, phenytoin, rifampin, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

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