Medicine Raw Material Paclitaxel For Cancer Treatment Drug Natural
|Shelf life||2 years|
|ASSAY (calculated on the anhydrous, solvent-free basis)||97.0%～102.0%||99.7%|
|IDENTIFICATION||IR Infrared Absorption:In accordance with the reference Standard
spectrum of paclitaxel||Conforms|
|Baccatin III||NMT 0.2%||0.08%|
|10-Deacetylbaccatin III||NMT 0.1%||Undetected|
|13-Tes-baccatin III||NMT 0.1%||Undetected|
|Others||NMT 0.1% (each)||0.04%|
|Acetone||NMT 5000ppm||33 ppm|
|RESIDUE ON IGNITION||NMT 0.2%||0.06%|
|HEAVY METALS||NMT 0.002%||Conforms|
|BACTERIAL ENDOTOXINS||NMT 0.4 EU/mg||Conforms|
|MICROBIAL LIMITS||Total aerobic microbial count NMT100 cfu/g||1 cfu/g|
|Salmonella species||It meets the requirements of the tests for the absence of
Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella species,
and Escherichia coli||Undetected|
|CONCLUSION||The product is in accordance withUSP34 to test the above-mentioned
items,||conform to the specification|
|1||Paclitaxel is a cancer medication that interferes with the growth
and spread of cancer cells in the body.|
Paclitaxel is used to treat breast cancer, ovarian cancer, and lung
cancer. It is also used to treat AIDS-related Kaposi's sarcoma.
Paclitaxel may also be used for purposes not listed in this
|4||Paclitaxel can lower blood cells that help your body fight
infections and help your blood to clot. You may get an infection or
bleed more easily. Call your doctor if you have unusual bruising or
bleeding, or signs of infection (fever, chills, body aches).|
Get emergency medical help if you have signs of an allergic
reaction: hives; difficult breathing; feeling like you might pass
out; swelling of your face, lips, tongue, or throat.
How you have paclitaxel
You usually have paclitaxel as an injection into a vein. It can
cause an allergic reaction. To try to prevent this, you have a
steroid injection and tablets before the paclitaxel drip. You also
have anantihistamine (such as chlorphenamine) into a vein about an
hour before your treatment. You will also have a medicine to
prevent heartburn, such as ranitidine or cimetidine. Abraxane does
not usually cause an allergic reaction so you don't need the anti
allergy drugs with abraxane.
You can have paclitaxel through a thin, short tube (a cannula) put
into a vein in your arm each time you have treatment. Or you may
have it through a central line, a portacath or a PICC line. These
are long, plastic tubes that give the drugs directly into a large
vein in your chest. You have the tube put in just before your
course of treatment starts and it stays in place as long as you
You usually have chemotherapy as a course of several cycles of
treatment. The treatment plan for paclitaxel depends on which
cancer you have. You can find out about how doctors plan
chemotherapy in the chemotherapy section.
Paclitaxel side effects are listed below. You can use the
underlined links to find out more about each side effect. Where
there is no link, use the search box at the top of the page or go
to our cancer drugs side effects section.
Occasional side effects
- fever, chills, body aches, flu symptoms, sores in your mouth and
- pale skin, feeling light-headed or short of breath, rapid heart
rate, trouble concentrating;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum),
purple or red pinpoint spots under your skin;
- flushing (warmth, redness, or tingly feeling);
- slow heart rate, feeling like you might pass out;
- seizure (convulsions);
- chest pain, dry cough, wheezing, feeling short of breath;
- numbness, tingling, or burning pain in your hands or feet;
- jaundice (yellowing of the skin or eyes); or
- severe redness or swelling, severe irritation, a hard lump, or skin
changes where the injection was given.
Common side effects may include:
- mild nausea, vomiting, diarrhea, constipation;
- joint or muscle pain;
- darkening of your skin or nails; or
- temporary hair loss.
Important points to remember
You should not receive this medication if you are allergic to
paclitaxel, or to other medications that contain an ingredient
called Cremophor EL (polyoxyethylated castor oil). This includes
cyclosporine and teniposide.
To make sure paclitaxel is safe for you, tell your doctor if you
- HIV, AIDS, or Kaposi's sarcoma;
- heart disease;
- high blood pressure; or
- liver disease.
- Do not receive paclitaxel if you are pregnant. It could harm the
unborn baby. Use effective birth control, and tell your doctor if
you become pregnant during treatment.
It is not known whether paclitaxel passes into breast milk or if it
could harm a nursing baby. You should not breast-feed while you are
Paclitaxel is injected into a vein through an IV. A healthcare
provider will give you this injection. You may be given other
medications to prevent an allergic reaction while you are receiving
Paclitaxel is usually given once every 3 weeks. Follow your
doctor's dosing instructions very carefully.
Your breathing, blood pressure, oxygen levels, kidney function, and
other vital signs will be watched closely while you are receiving
Tell your caregivers if you feel any burning, pain, or swelling
around the IV needle when paclitaxel is injected.
Paclitaxel can lower blood cells that help your body fight
infections and help your blood to clot. Your blood will need to be
tested often. Your cancer treatments may be delayed based on the
results of these tests.