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Oral Spironolactone Powder , CAS 52-01-7 API High Blood Pressure Drugs

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Oral Spironolactone Powder , CAS 52-01-7 API High Blood Pressure Drugs

Brand Name : Jusheng Brand
Model Number : 52-01-7
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 52-01-7
Apparence : white powder
Purity : 99%
Storage : Shading, Confined Preservation
Stock : Enough Stock
Grade : Pharma Grade
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Oral High Blood Pressure Treatment Raw Material Powder Spironolactone 52-01-7 API


Quick detail


Name:Spironolactone
CAS No.:52-01-7
Formula:C24H32O4S
Molecular Weight:416.62
Synonyms:Alderon;3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alph a.-yl)propionic acid lactone;Uractone;Spiro(17H-cyclopenta(a)phenauthrene-17,2-(3H)-furan);Xenalon;Pregn-4-ene-21-carboxylic acid
EINECS:200-133-6
Density:1.24 g/cm3
Melting Point:207-208 °C(lit.)
Boiling Point:597 °C at 760 mmHg
Flash Point:302.3 °C
Solubility:practically insoluble in water
Appearance:White to Off White Solid

Spironolactone​ ​Description


Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.


Spironolactone is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone. This medicine may also be used to treat fluid retention (edema) in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome.


Spironolactone is a potassium-sparing diuretic (water pill). It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood).


Treatment by Condition Related to spironolactone


  • Diastolic Heart Failure Medications
  • Aldosteronism Medications
  • High Blood Pressure Medications
  • Chronic Heart Failure Medications
  • Accumulation of Fluid Resulting from Chronic Heart Failure Medications
  • Fluid in the Lungs due to Chronic Heart Failure Medications
  • Accumulation of Fluid caused by Cirrhosis of the Liver Medications
  • Accumulation of Fluid caused by Kidney Disease Medications
  • Male Pattern of Hair Distribution or Hirsutism in a Woman Medications
  • Visible Water Retention Medications
  • Ascites Medications
  • Diagnostic Test for Primary Hyperaldosteronism Medications
  • Disease of Ovaries with Cysts Medications
  • Low Amount of Potassium in the Blood Medications
  • Prevention of Low Potassium in the Blood Medications


Spironolactone Specification:


Test ItemsSpecificationTest Results
AppearanceAlmost white crystalline powderAlmost white crystalline powder
IdentificationMeet the requirementsMeet the requirements
Melting range

198℃~209℃

Between 198℃ and 209℃

205.0℃~207.0℃
Specific rotation

-33°~-37°

Between -33° and -37°

-35°
Loss on drying

≤0.5%

Not more than 0.5%

0.2%
Limit of mercapto compoundsMeet the requirementsMeet the requirements
Ordinary impuritiesMeet the requirementsMeet the requirements
Organic volatile impuritiesMeet the requirementsMeet the requirements
Assay(on the dried basis)

97.0%~103.0%(C24H32O4S)

Between 97.0% and 103.0%

98.99%
ConclusionMeet the requirements of USP29

Spironolactone Dosage


Spironolactone comes as 25 milligrams (mg), 50 mg, and 100 mg oral tablets.

Dosage depends on your health issue:

Primary hyperaldosteronism: 100 to 400 mg daily
Edema: 25 to 200 milligrams every day, for at least 5 days
Essential hypertension: 50 to 100 mg every day, for at least two weeks
Hypokalemia: 25 to 100 mg once daily
Severe heart failure: 25 mg once daily, which may be increased to 50 mg once daily or decreased to 25 mg once every other day, depending on your tolerance of the drug


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