Oral Corticosteroids Betamethasone 378-44-9 Anti - Inflammatory
|Melting Point:||235-237 °C|
|Boiling Point:||568.2 °C at 760 mmHg|
|Flash Point:||297.5 °C|
|Appearance:||white to off-white solid|
Introduction of Betamethasone
Betamethasone, belongs to adrenal corticosteroids, it is a isomer
of dexamethasone , and the role of betamethasone is similiar to
prednisolone and dexamethasone , it has anti-inflammatory,
anti-rheumatic, anti-allergic and suppression of the immune and
other pharmacological effects, its anti-inflammatory effect is
stronger than dexamethasone, triamcinolone, hydrocortisone etc. ,
Betamethasone sodium retention effect is a hundred times more than
hydrocortisone, in primary adrenal hypofunction, it can be used
together with glucocorticoid for replacement therapy ,and it is
used for preventing or inhibiting cell-mediated immune response,
delaying allergic reactions and reducing the primary immune
response expansion ,it is used for low renin and low aldosterone
syndrome and autonomic neuropathy induced orthostatic hypotension.
Currently betamethasone is also used for the treatment of active
rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial
asthma, severe dermatitis, acute leukemia, atopic dermatitis,
eczema, neurodermatitis, seborrheic dermatitis, and pruritus and
comprehensive treatment of certain infections.
- Hormone drugs.
- It is mainly used for anti-inflammatory and anti-allergic.
- It is suitable for rheumatoid arthritis and various skin diseases.
- Betamethasone role is similiar to dexamethasone,
- its anti-inflammatory effect is stronger than dexamethasone,
triamcinolone, hydrocortisone and it has few side effects.
Technical Test Sheet (TTS) of Glucocorticoid Steroids Betamethasone
|Identification (B,C)||Complies with the Standard||Complies|
|Specific optical Rotation||+118°~+126°||+123.5°|
|Single impurity||Not more than 1.0%||0.29%|
|impurity that ≥0.5%||Not more than one||Complies|
|total impurities||Not more than 2.0%||0.64%|
|Loss on drying||Not more than 1.0%||0.05%|
|Assay(UV, basis on drying)||97.0%~103.0%||98.8%|
|Methanol||Not more than 3000ppm||Complies|
|Ethyl acetate||Not more than 5000ppm||Complies|
|Acetone||Not more than 5000ppm||Complies|
|DMF||Not more than 880ppm||Complies|
|Dichloromethane||Not more than 600ppm||Complies|
|Chloroform||Not more than 60ppm||Complies|
|Residue on ignition||Not more than 0.2%||0.03%|