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MKC-231 Best Nootropic For Memory , 135463-81-9 Brain Smart Supplement Powder

MKC-231 Best Nootropic For Memory , 135463-81-9 Brain Smart Supplement Powder

Brand Name : Jusheng Brand
Model Number : 135463-81-9
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Other Name : MKC-231, Coluracetam
Molecular Formula : C19H23N3O3
Apparence : Almost White Crystalline Powder
Purity : More Than 98%
MOQ : 10grams
Packing : As Your Requirement
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MKC-231 Coluracetam Brain health drug Nootropic Supplements 135463-81-9 Powder

Nootropic Supplements product list.pdf

Quick detail

  • Name: Coluracetam
  • Other names: BCI-540; MKC-231
  • CAS#: 135463-81-9
  • Molecular formula: C19H23N3O3
  • Molecular weight: 341.404
  • Density: 1.3
  • Melting point: ºC
  • Boiling point: 634.1ºC
  • Flash point: 337.3ºC
  • Solubility: soluble in DMSO and Ethanol
  • Stability:
  • Appearance: white powder
  • Purity: 99%
  • Introduction:
  • Coluracetam is a nootropic agent of the racetam family. It would be a potential medication for comorbid major depressive disorder (MDD) with generalized anxiety disorder (GAD). It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
  • Coluracetam is also considered a potential therapeutic drug for schizophrenia.

Coluracetam​ Introduction

Coluracetam (MKC-231) is a synthetic racetam drug purported to be a nootropic compound. It does not have a large body of evidence investigating it, but the mechanisms of action (as well as structute) appear to be very distinct from other racetam compounds like Piracetam or Aniracetam.
Coluracetam appears to interact with a process known as high affinity choline uptake (HACU for short), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increasing the HACU rate appears to increase the activity of cholinergic neurons, so it is a desired target for cognitive enhancement.

Interventions in rats (as there is no human evidence currently) support the usage of coluracetam at very low oral doses to preserve HACU that is otherwise impaired by the use of research drugs that are known to impair HACU. The limited evidence looking at the inherent effects of coluracetam on the HACU of normal neurons has failed to find any significant interaction.

Coluracetam has also been noted to associate with choline transporters physically, but it is not known exactly what it does once associated.

Overall, there is currently insufficient evidence to support the usage of coluracetam for cognitive enhancement. Further studies are needed to see if it has a therapeutic role in instances where HACU may be impaired (such as Alzheimer's disease).

Things to Note

  1. Piracetam is water-soluble, and does not need to be taken with food
  2. Many studies note a high inter-individual variability
  3. It is (anecdotally) reported to be non-stimulatory and non-sedative
How to Take Coluracetam

Recommended dosage, active amounts, other details
The animal research on coluracetam uses an oral dose of 300-3,000mcg bodyweight, which is roughly translated into a human dose of 48-480mcg or (for a 150lb person) 3.2-32.7mg overall.

It appears to have very rapid kinetics, with a peak in blood at around 30 minutes and on the decline within 3 hours. Due to this, supplementation may be time-dependent in relation to activity.


The action mechanisms of piracetam are still vaguely understandable even though various clinical and experimental studies have been conducted. Nevertheless, this remarkable smart drug is used for the modulation of membrane fluidity. As a consequence, it demonstrates certain effects on the release of neurotransmitters and receptor binding. It also results in improved cell functioning and better viscosity of cell membranes. In addition, piracetam “appears to reduce erythrocyte adhesion to vascular endothelium, hinder vasospasm, and facilitate microcirculation” at a vascular level.

Moreover, it is also known to have an involvement in the activation of acetylcholine, which helps the brain to take up oxygen with improved blood flow. Piracetam is also considered a great promoter of information transference from one brain hemisphere to the other. It enhances motor planning by creating a coordination between both hemispheres.


  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
BrivaracetamCAS 357336-20-0
EtiracetamCAS 3996-58-6
OxiracetamCAS 62613-82-5
AniracetamCAS 72432-10-1
LevetiracetamCAS 102767-28-2
NefiracetamCAS 77191-36-7
PramiracetamCAS 68497-62-1
PiracetamCAS 7491-74-9

Product Tags:

brain enhancing supplements


cognitive enhancing drugs

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