MKC-231 Coluracetam Brain health drug Nootropic Supplements
Nootropic Supplements product list.pdf
- Name: Coluracetam
- Other names: BCI-540; MKC-231
- CAS#: 135463-81-9
- Molecular formula: C19H23N3O3
- Molecular weight: 341.404
- Density: 1.3
- Melting point: ºC
- Boiling point: 634.1ºC
- Flash point: 337.3ºC
- Solubility: soluble in DMSO and Ethanol
- Appearance: white powder
- Purity: 99%
- Coluracetam is a nootropic agent of the racetam family. It would be
a potential medication for comorbid major depressive disorder (MDD)
with generalized anxiety disorder (GAD). It may also have potential
use in prevention and treatment of ischemic retinopathy and retinal
and optic nerve injury.
- Coluracetam is also considered a potential therapeutic drug for
Coluracetam (MKC-231) is a synthetic racetam drug purported to be a
nootropic compound. It does not have a large body of evidence
investigating it, but the mechanisms of action (as well as
structute) appear to be very distinct from other racetam compounds
like Piracetam or Aniracetam.
Coluracetam appears to interact with a process known as high
affinity choline uptake (HACU for short), which is the
rate-limiting step of drawing choline into a neuron for synthesis
into the neurotransmitter acetylcholine. Increasing the HACU rate
appears to increase the activity of cholinergic neurons, so it is a
desired target for cognitive enhancement.
Interventions in rats (as there is no human evidence currently)
support the usage of coluracetam at very low oral doses to preserve
HACU that is otherwise impaired by the use of research drugs that
are known to impair HACU. The limited evidence looking at the
inherent effects of coluracetam on the HACU of normal neurons has
failed to find any significant interaction.
Coluracetam has also been noted to associate with choline
transporters physically, but it is not known exactly what it does
Overall, there is currently insufficient evidence to support the
usage of coluracetam for cognitive enhancement. Further studies are
needed to see if it has a therapeutic role in instances where HACU
may be impaired (such as Alzheimer's disease).
Things to Note
- Piracetam is water-soluble, and does not need to be taken with food
- Many studies note a high inter-individual variability
- It is (anecdotally) reported to be non-stimulatory and non-sedative
How to Take Coluracetam
Recommended dosage, active amounts, other details
The animal research on coluracetam uses an oral dose of
300-3,000mcg bodyweight, which is roughly translated into a human dose of
48-480mcg or (for a 150lb person) 3.2-32.7mg overall.
It appears to have very rapid kinetics, with a peak in blood at
around 30 minutes and on the decline within 3 hours. Due to this,
supplementation may be time-dependent in relation to activity.
HOW DOES PIRACETAM WORK?
The action mechanisms of piracetam are still vaguely understandable
even though various clinical and experimental studies have been
conducted. Nevertheless, this remarkable smart drug is used for the
modulation of membrane fluidity. As a consequence, it demonstrates
certain effects on the release of neurotransmitters and receptor
binding. It also results in improved cell functioning and better
viscosity of cell membranes. In addition, piracetam “appears to
reduce erythrocyte adhesion to vascular endothelium, hinder
vasospasm, and facilitate microcirculation” at a vascular level.
Moreover, it is also known to have an involvement in the activation
of acetylcholine, which helps the brain to take up oxygen with
improved blood flow. Piracetam is also considered a great promoter
of information transference from one brain hemisphere to the other.
It enhances motor planning by creating a coordination between both
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