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Anti Depressant MKC-231 Brain Enhancing Drugs Coluracetam CAS 135463-81-9

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Anti Depressant MKC-231 Brain Enhancing Drugs Coluracetam CAS 135463-81-9

Brand Name : Jusheng Brand
Model Number : 135463-81-9
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T, Western Union, MoneyGram, L/C, Bitcion, Paypal
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 135463-81-9
Molecular Formula : C19H23N3O3
Apparence : Almost White Crystalline Powder
Purity : More Than 98%
MOQ : 10grams
Packing : As Your Requirement
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Anti-depressant MKC-231 Coluracetam Nootropic Raw Material Drug 135463-81-9

Quick detail


Name:

Coluracetam

Other names:
BCI-540; MKC-231
CAS#:135463-81-9
Molecular formula:
C19H23N3O3
Molecular weight:
341.404
Density:1.3
Boiling point:634.1ºC
Flash point:
337.3ºC
Solubility:soluble in DMSO and Ethanol
Appearance:white powder
Purity:99%

Coluracetam​ Introduction


1Coluracetam (MKC-231) is a synthetic racetam drug purported to be a nootropic compound. It does not have a large body of evidence investigating it, but the mechanisms of action (as well as structute) appear to be very distinct from other racetam compounds like Piracetam or Aniracetam.
2Coluracetam appears to interact with a process known as high affinity choline uptake (HACU for short), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increasing the HACU rate appears to increase the activity of cholinergic neurons, so it is a desired target for cognitive enhancement.
3

Coluracetam is a nootropic agent of the racetam family. It would be a potential medication for comorbid major depressive disorder (MDD) with generalized anxiety disorder (GAD). It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.

Coluracetam is also considered a potential therapeutic drug for schizophrenia.


Coluracetam Dosing


Of the studies cited done on adult rats, the dosing schedule ranged anywhere from 1mg/kg up to 10mg/kg in (per day) . At the high end of that range, the dosing (accounting for Allometric scaling) in an average adult human would be equivalent to 2.9mg/kg; this would work out to 203.5mg/day for someone of an average weight.

BrainCells Inc. also recently concluded Phase 2A trials of Coluracetam, under the name BCI-540, where they administered up to 80mg three times per day for Major Depressive Disorder in adult humans (or 1.14mg/kg in an average weight human); 36% of participants showed improvements in their scores on two tests for MDD


Benefits of Coluracetam


  1. The first noted benefit of Coluracetam is in ameliorating the effects of glutamate neurotoxicity; cortical cultures were taken from fetal rats that had been treated with a substance that causes glutamate toxicity and these cultures were treated with Coluracetam for 12 to 24 hours. After this exposure period, it was found that Coluracetam ameliorated the effects of the exposure.
  2. The second noted benefit of Coluracetam was in reducing the effects of learning deficits in rats, using the Morris Water Maze as a test. Adult rats in the experimental group were treated with a cholinergic neuron-specific neurotoxin and the control group was a population of healthy rats.


Coluracetam’s Mechanism of Action


Coluracetam appears to have two well-defined mechanisms of action; the first being high-affinity choline uptake, and the other being AMPA potentiation [3]. As is the case with a few of the Racetams, Coluracetam has been show to facilitate AMPA potentiation which is known to increase alertness, memory, and learning capabilities. What is more intriguing about Coluracetam are its high-affinity choline uptake properties; choline uptake plays a crucial role in the Acetylcholine synthesis process in the brain by acting as a rate-limiter. This rate-limiting step allows the brain to convert choline into Acetylcholine in the neuron, and by increasing the high-affinity choline uptake the brain is more readily able to convert choline to Acetylcholine; by increasing the ability to convert choline to Acetylcholine, should in theory improve attention, memory, and wakefulness in humans.


Warnings

  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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